Microfrabricated in-vitro cell culture systems for investigating cellular interactions: fabricating a model system for cardiac myocytes

Jennifer Deutsch; Tejal A. Desai; Delara Motlagh; Brenda Russell

doi:10.1117/12.379567

15 March 2000 Microfrabricated in-vitro cell culture systems for investigating cellular interactions: fabricating a model system for cardiac myocytes

Jennifer Deutsch, Tejal A. Desai, Delara Motlagh, Brenda Russell

Author Affiliations +

Proceedings Volume 3912, Micro- and Nanotechnology for Biomedical and Environmental Applications; (2000) https://doi.org/10.1117/12.379567
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

The use of microfabricated and micromachined substrates can aid in the creation of design two- and three-dimensional microstructures, scaffolds, and platforms for cell culture and tissue engineering. These platforms may offer several advantages for in vitro cell culture by providing (1) well controlled microarchitectures, (2) spatial localization of different cell populations, and (3) biochemically modified substrates to promote selective protein and/or cell attachment. The development of methodologies to create microfabricated tissue engineering constructs using traditional natural and polymeric biomaterials may allow us to engineer highly controlled interfaces in order to better understand and modulate cell behavior and have the capability to provide: more physiologically relevant models of cell and tissues in vitro. This paper describes the use of microfabricated cell culture platforms to study cardiac myocytes.

Citation Download Citation

Jennifer Deutsch, Tejal A. Desai, Delara Motlagh, and Brenda Russell "Microfrabricated in-vitro cell culture systems for investigating cellular interactions: fabricating a model system for cardiac myocytes", Proc. SPIE 3912, Micro- and Nanotechnology for Biomedical and Environmental Applications, (15 March 2000); https://doi.org/10.1117/12.379567

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