Characterization of normal and native oral cancerous tissues by infrared spectroscopy

Nammalver Vengadesan; D. Koteeswaran; Prakasa Rao Aruna; K. Muthuvelu; Singaravelu Ganesan

doi:10.1117/12.384954

8 May 2000 Characterization of normal and native oral cancerous tissues by infrared spectroscopy

Nammalver Vengadesan, D. Koteeswaran, Prakasa Rao Aruna, K. Muthuvelu, Singaravelu Ganesan

Proceedings Volume 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques; (2000) https://doi.org/10.1117/12.384954
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Fourier transform IR spectroscopy of normal and cancerous human oral tissues have been studied in the mid IR frequency region. From this study, we observed that the cancerous tissues are having higher absorption than that of normal one. Further it is observed that there is a 13 cm^-1 red shift for cancerous samples with respect to normal tissues at their maximum absorption. In order to quantify the spectral differences between normal and cancerous tissues, two ratio parameters R₁ equals I₁₆₅₀/I₁₅₄₆ and R₂ equals I₁₆₅₀/I₁₃₈₄ are introduced. From the ratio parameter R₁, it is found that the critical value 2.1 classify the malignant from normal with a 93 percent sensitivity and 80 percent specificity. Similarity a critical value 3 is given for the ratio parameter R₂ yielding 80 percent sensitivity and 100 percent specificity.

Citation Download Citation

Nammalver Vengadesan, D. Koteeswaran, Prakasa Rao Aruna, K. Muthuvelu, and Singaravelu Ganesan "Characterization of normal and native oral cancerous tissues by infrared spectroscopy", Proc. SPIE 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, (8 May 2000); https://doi.org/10.1117/12.384954

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KEYWORDS

Tissues

Absorption

Cancer

Spectroscopy

Infrared spectroscopy

FT-IR spectroscopy

Proteins

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