Dynamic changes in the elastic modulus of lagomorph nasal septal cartilage during Nd:YAG (lambda = 1.32 um) laser irradiation

Kenneth K. H. Chao; Matt A. Burden; Brian Jet-Fei Wong M.D.

doi:10.1117/12.434708

9 July 2001 Dynamic changes in the elastic modulus of lagomorph nasal septal cartilage during Nd:YAG (λ = 1.32 μm) laser irradiation

Kenneth K. H. Chao, Matt A. Burden, Brian Jet-Fei Wong M.D.

Author Affiliations +

Proceedings Volume 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical; (2001) https://doi.org/10.1117/12.434708
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The elastic modulus of rabbit nasal septal cartilage was measured during Nd:YAG laser (λ= 1.32 μm, 10 seconds, 21.22 W/cm²) radiation. Cyclical force versus displacement curves were generated in cantilevered specimens (9.5 mm x 3.0 mm x 1.0 mm) using a calibrated thin beam load cell and a single axis motorized micropositioner (velocity = 0.3 mm/sec). The laser and a thermopile were positioned above the secured specimen. Samples were irradiated three times with 30 second cooling intervals between each sequential laser exposure. Surface temperature reached a maximum of 65°C. Measurements were recorded before, during, and after each laser irradiation, and then following complete rehydration in normal saline (NS) for 1 hour at 25°C. Following each laser exposure, the sample was sprayed with normal saline delivered via an atomizer to prevent desiccation. Elastic modulus was calculated using a model assuming linear elastic behavior. The modulus in native tissue was 6.08 ± 0.17 Mpa, and this decreased during and after each successive laser exposure (5.41 ± 0.39 Mpa, 4.94 ± 0.46), (5.05 ± 0.104 Mpa, 4.17 ± 0.46 Mpa), (4.23 ± 0.53, 3.71 ± 0.60 Mpa), for the first, second, and third laser exposures, respectively. Following rehydration for one hour in normal saline, the modulus returned to near-baseline values (5.33 ± 0.40 Mpa). The results suggest that molecular changes that occur in the cartilage tissue matrix during laser cartilage reshaping are not accompanied by irreversible changes in the matrix modules.

Citation Download Citation

Kenneth K. H. Chao, Matt A. Burden, and Brian Jet-Fei Wong M.D. "Dynamic changes in the elastic modulus of lagomorph nasal septal cartilage during Nd:YAG (λ = 1.32 μm) laser irradiation", Proc. SPIE 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical, (9 July 2001); https://doi.org/10.1117/12.434708

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