Standard and high-throughput microfluidic disposables based on laminar fluid diffusion interfaces

Bernhard H. Weigl; Chris Morris; Natasa Kesler; Fred Battrell; Ron L. Bardell

doi:10.1117/12.472108

21 June 2002 Standard and high-throughput microfluidic disposables based on laminar fluid diffusion interfaces

Bernhard H. Weigl, Chris Morris, Natasa Kesler, Fred Battrell, Ron L. Bardell

Author Affiliations +

Proceedings Volume 4626, Biomedical Nanotechnology Architectures and Applications; (2002) https://doi.org/10.1117/12.472108
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Laminar Fluid Diffusion Interfaces are generated when tow or more streams flow in parallel in a microfluidic structure. This technology can be used for diffusion-based separation and detection applications, for example: DNA desalting, the extraction of small proteins from whole-blood samples, and the detection of various constituents in while blood. Additional applications are the establishment of stable concentration gradients, and the exposure of chemical constituents or biological particles to these concentration gradients, enabling the uniform and controlled exposure of cells to lysing agents, allowing the differentiation of cells by their sensitivity to specific agents in an on-chip cytometer coupled directly to the lysing structure. We have developed integrated systems using machine-controlled disposable cartridges and passive self-contained disposable cards including particle separators, flow cytometers, valves, detection channels, mixers, and diluters that are used in a hematology analyzer, stand-alone blood plasma separators, and a variety of chemical and biological assays. Microfluidic arrays compatible with common well-plate formats have been designed for high-throughout toxicology screening applications. All these devices were manufactured using Micronics' unique rapid-prototyping process yielding low-cost plastic disposable microfluidic chips.

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Bernhard H. Weigl, Chris Morris, Natasa Kesler, Fred Battrell, and Ron L. Bardell "Standard and high-throughput microfluidic disposables based on laminar fluid diffusion interfaces", Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); https://doi.org/10.1117/12.472108

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