Prototype system of laser transillumination computed tomography for early diagnosis of rheumatoid arthritis

Yoshiaki Sasaki; Shinji Tanosaki; Jota Suzuki; Ryota Emori; Hiroki Inage; Tetsuya Yuasa; Michiaki Takagi; Akira Ishikawa; Hiroshi Taniguchi; Balasigamani Devaraj; Takao Akatsuka

doi:10.1117/12.478067

1 July 2003 Prototype system of laser transillumination computed tomography for early diagnosis of rheumatoid arthritis

Yoshiaki Sasaki, Shinji Tanosaki, Jota Suzuki, Ryota Emori, Hiroki Inage, Tetsuya Yuasa, Michiaki Takagi, Akira Ishikawa, Hiroshi Taniguchi, Balasigamani Devaraj, Takao Akatsuka

Author Affiliations +

Proceedings Volume 4957, Optical Fibers and Sensors for Medical Applications III; (2003) https://doi.org/10.1117/12.478067
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

So far we have shown, through various preliminary imaging experiments with small-animal ankle’s and human finger’s joints both healthy and joint-diseased, that early diagnosis for joint disease such as rheumatoid arthritis (RA) is feasible using a transillumination laser CT. For a practical purpose, we have recently proposed and developed a transillumination laser CT imaging system using optical fibers based on the optical heterodyne detection method for a clinical use. In the proposed system, motion-artifact free images can be obtained because measurements can be performed with the object fixed. In addition, use of fiber-optics enables portability, and robustness against environmental changes in a room, such as variable temperature, air-flow shifts, and unexpected vibrations. The imaging system has the following sensing properties: spatial resolution of 500 μm, a dynamic range of approximately 120 dB, and a minimum-detectable-optical power of 10^-14 W as a result of the excellent properties of the heterodyne detection technique. In the present paper, we describe a prototype laser CT imaging system using optical fibers for early diagnosis of joint disease such as rheumatoid arthritis by demonstrating the first in vivo tomographic image of a volunteer’s index finger joint as well as the fundamental imaging properties.

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Yoshiaki Sasaki, Shinji Tanosaki, Jota Suzuki, Ryota Emori, Hiroki Inage, Tetsuya Yuasa, Michiaki Takagi, Akira Ishikawa, Hiroshi Taniguchi, Balasigamani Devaraj, and Takao Akatsuka "Prototype system of laser transillumination computed tomography for early diagnosis of rheumatoid arthritis", Proc. SPIE 4957, Optical Fibers and Sensors for Medical Applications III, (1 July 2003); https://doi.org/10.1117/12.478067

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