Compact single-channel Raman detector for macular pigments

Igor V. Ermakov; Maia R. Ermakova; Werner Gellermann

doi:10.1117/12.529774

13 July 2004 Compact single-channel Raman detector for macular pigments

Igor V. Ermakov, Maia R. Ermakova, Werner Gellermann

Author Affiliations +

Proceedings Volume 5314, Ophthalmic Technologies XIV; (2004) https://doi.org/10.1117/12.529774
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Raman detection of macular pigments (MP) holds promise as a novel noninvasive technology for the quantification of lutein and zeaxanthin carotenoids, which are thought to prevent or delay the onset of age-related macular degeneration. Using resonant excitation in the visible, we measure the Raman signals that originate from the double-bond stretch vibrations of the p-conjugated carotenoid molecule's carbon backbone. In this paper we describe the construction and performance of a new, compact, and low-cost MP Raman instrument using dielectric, angle-tuned band-pass filters for wavelength selection and single-channel photo-multiplier detection of carotenoid Raman responses. MP concentration measurements are fast and accurate, as seen in experiments with model eyes and living human eyes. The ease and rapidity of Raman MP measurements, the relative simplicity of the instrumentation, the high accuracy of the measurements, and the lack of significant systematic errors should make this technology useful for widespread clinical research.

Citation Download Citation

Igor V. Ermakov, Maia R. Ermakova, and Werner Gellermann "Compact single-channel Raman detector for macular pigments", Proc. SPIE 5314, Ophthalmic Technologies XIV, (13 July 2004); https://doi.org/10.1117/12.529774

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE