Newt limb regeneration studied with synchrotron micro-CT

Stuart R. Stock; Konstantin I. Ignatiev; Hans-Georg Simon; Francesco De Carlo

doi:10.1117/12.560472

26 October 2004 Newt limb regeneration studied with synchrotron micro-CT

Stuart R. Stock, Konstantin I. Ignatiev, Hans-Georg Simon, Francesco De Carlo

Proceedings Volume 5535, Developments in X-Ray Tomography IV; (2004) https://doi.org/10.1117/12.560472
Event: Optical Science and Technology, the SPIE 49th Annual Meeting, 2004, Denver, Colorado, United States

Abstract

Newts are the most developed vertebrates which retain the ability as adults to regenerate missing limbs; they are, therefore, of great interest in terms understanding how such regeneration could be triggered in mammals. In this study, synchrotron microCT was used to study bone microstructure in control forelimbs and in forelimbs regenerated for periods from 37 to 85 days. The bone microstructure in newts has been largely neglected, and interesting patterns within the original bone and in the regenerating arm and hand are described. Periosteal bone formation in the regenerating arm and finger bones, delayed ossification of carpal (but not metacarpal) bones and the complex microstructure of the original carpal bones are areas where microCT reveals detail of particular interest.

Citation Download Citation

Stuart R. Stock, Konstantin I. Ignatiev, Hans-Georg Simon, and Francesco De Carlo "Newt limb regeneration studied with synchrotron micro-CT", Proc. SPIE 5535, Developments in X-Ray Tomography IV, (26 October 2004); https://doi.org/10.1117/12.560472

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