The mechanism of electrostatic interaction between biological molecules and nanometal colloid on near-infrared surface-enhanced Raman scattering

Haiying Zhao; Xiaoming Dou

doi:10.1117/12.575721

18 January 2005 The mechanism of electrostatic interaction between biological molecules and nanometal colloid on near-infrared surface-enhanced Raman scattering

Haiying Zhao, Xiaoming Dou

Author Affiliations +

Proceedings Volume 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II; (2005) https://doi.org/10.1117/12.575721
Event: Photonics Asia, 2004, Beijing, China

Abstract

This paper reports effects of electrostatic interaction between amino acid and gold colloid on the intensity of surface-enhanced raman scattering (SERS). Near-infrared (NIR) excited SERS has been measured for lysine (Lys) on gold colloid at pH 10.8 and 12.0 where its ε-amino group is ionized and both the α- and ε-amino groups are neutralized, respectively. Note that the SERS intensity changes dramatically with pH. This result suggests that the electrostatic interaction between the positive charge of the ε-NH₃⁺ group and the negative charge of the gold surface is one of the most important factors that determine the intensities of the SERS signals.

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Haiying Zhao and Xiaoming Dou "The mechanism of electrostatic interaction between biological molecules and nanometal colloid on near-infrared surface-enhanced Raman scattering", Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); https://doi.org/10.1117/12.575721

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