Laser-induced photoacoustic imaging for characterizing biological tissues

Yasser H. El-Sharkawy M.D.; Yehia Badr D.D.S.; Mahmoud Hassan

doi:10.1117/12.581462

8 April 2005 Laser-induced photoacoustic imaging for characterizing biological tissues

Yasser H. El-Sharkawy M.D., Yehia Badr D.D.S., Mahmoud Hassan

Proceedings Volume 5689, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV; (2005) https://doi.org/10.1117/12.581462
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Time-resolved photoacoustic imaging has been used to characterize Breast tissues for the purpose of discriminating between normal and Cancerous tumor areas of tissue. Ultrasonic thermoelastic waves were generated in Breast tissue by the absorption of nanosecond laser pulses at 193 nm produced by a frequency doubled Q-switched excimer laser in conjunction with an optical interferometer sensor was used to detect the thermoelastic and thermal waves. At 193 nm, differences in photoacoustic and photothermal signatures of normal tissue and Cancerous tumor were found to be highly enhanced. There was a clear and reproducible difference between the photacoustic and photothermal response of Cancerous tumor and normal tissue as a result of increased optical attenuation in Cancerous tumor. At 193 nm, the generation of subsurface thermoelastic waves provided a means of determining the structure and thickness of the tissue sample. The thermal waves provided a mean of determination the optical absorption of the tissue sample.

Citation Download Citation

Yasser H. El-Sharkawy M.D., Yehia Badr D.D.S., and Mahmoud Hassan "Laser-induced photoacoustic imaging for characterizing biological tissues", Proc. SPIE 5689, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV, (8 April 2005); https://doi.org/10.1117/12.581462

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available