Induction of anti-tumor immunity by photodynamic therapy (PDT)

Sandra O. Gollnick; Barbara Owczarczak; Patricia Maier

doi:10.1117/12.649852

23 February 2006 Induction of anti-tumor immunity by photodynamic therapy (PDT)

Sandra O. Gollnick, Barbara Owczarczak, Patricia Maier

Proceedings Volume 6087, Biophotonics and Immune Responses; 60870E (2006) https://doi.org/10.1117/12.649852
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Tumor directed PDT has been shown by a number of pre-clinical studies to enhance a specific anti-tumor immune response, which appears to be critical to long-term tumor growth control by PDT. The PDT enhanced immune response is T cell dependent, however the mechanism behind the potentiation of the immune response by PDT is unknown. Induction of T cell dependent immunity depends upon the presence of activated antigen presenting cells. Therefore we have examined the ability of PDT to stimulate maturation and activation of antigen presenting cells in the PDT-treated tumor bed and tumor draining lymph node. Our studies demonstrate and increase in the number of activated antigen presenting cells in the tumor bed 24h following treatment of EMT6 murine tumors with Photofrin-PDT. Tumor draining lymph nodes also showed increased levels of activated antigen presenting cells within 4h of treatment. The levels peaked at 24h and declined by 48h after PDT. These results demonstrate that PDT-enhanced anti-tumor immunity is accompanied by an increase in antigen presenting cell activity. Therefore it is possible that T cell dependent immunity is enhanced following PDT through enhanced antigen presenting cell activity.

Citation Download Citation

Sandra O. Gollnick, Barbara Owczarczak, and Patricia Maier "Induction of anti-tumor immunity by photodynamic therapy (PDT)", Proc. SPIE 6087, Biophotonics and Immune Responses, 60870E (23 February 2006); https://doi.org/10.1117/12.649852

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available