Spectroscopic modulation of multifunctionalized quantum dots for use as biological probes and effectors

Sandra Miskoski; Luciana Giordano; Maria H. Etchehon; Guillermo Menendez; Keith A. Lidke; Guy M. Hagen; Thomas M. Jovin; Elizabeth A. Jares-Erijman

doi:10.1117/12.649835

27 March 2006 Spectroscopic modulation of multifunctionalized quantum dots for use as biological probes and effectors

Sandra Miskoski, Luciana Giordano, Maria H. Etchehon, Guillermo Menendez, Keith A. Lidke, Guy M. Hagen, Thomas M. Jovin, Elizabeth A. Jares-Erijman

Author Affiliations +

Proceedings Volume 6096, Colloidal Quantum Dots for Biomedical Applications; 60960X (2006) https://doi.org/10.1117/12.649835
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Multifunctional nanoparticles, quantum dots (QDs) are being developed as uniquely sensitive tools for elucidating the (bio)chemical and (bio)physical molecular mechanisms underlying functional states, i.e. the molecular physiology, of biological cells and organisms. Here we present a group of strategies and examples for (i) controlling the spectroscopic properties of QDs via Fluorescence Resonance Energy Transfer (FRET); (ii) determining the emission spectra of individual QDs in a population with an imaging spectrograph (ASI SpectraCube); and (iii) employing such liganded QDs as nano-probes in cellular studies of signal transduction.

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Sandra Miskoski, Luciana Giordano, Maria H. Etchehon, Guillermo Menendez, Keith A. Lidke, Guy M. Hagen, Thomas M. Jovin, and Elizabeth A. Jares-Erijman "Spectroscopic modulation of multifunctionalized quantum dots for use as biological probes and effectors", Proc. SPIE 6096, Colloidal Quantum Dots for Biomedical Applications, 60960X (27 March 2006); https://doi.org/10.1117/12.649835

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