Application of optical coherence tomography for imaging of scaffold structure and micro-flows characterization

B. Veksler; E. Kobzev; M. Bonesi; Igor Meglinski

doi:10.1117/12.820993

30 December 2008 Application of optical coherence tomography for imaging of scaffold structure and micro-flows characterization

B. Veksler, E. Kobzev, M. Bonesi, Igor Meglinski

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Proceedings Volume 7139, 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics; 71390C (2008) https://doi.org/10.1117/12.820993
Event: 1st Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics, 2008, Canterbury, United Kingdom

Abstract

Tissue engineering, rapidly developing branch of bioscience, is widely adopted for the purposes of the tissue growing using the substrate materials. Three-dimensional porous scaffolds possess a great opportunity for the directional growth of the cells and for the supplying them with nutrients. However, the complex porous structure of the scaffolds creates difficulties for the measurements and control of nutrients flow. We applied optical coherence tomography (OCT) for imaging of the scaffold structure. We also investigated the possibility of using Doppler OCT to monitor the flow velocity distribution within the scaffold. The average scaffold's pore diameter has been estimated using electron microscopy. We show that with Doppler OCT it is possible to monitor complex micro-flow and estimate the shear stress (i.e. enhancing factor of cell growing) acting on the cells within the scaffold and to find the optimal input flow rate, consequently.

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B. Veksler, E. Kobzev, M. Bonesi, and Igor Meglinski "Application of optical coherence tomography for imaging of scaffold structure and micro-flows characterization", Proc. SPIE 7139, 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics, 71390C (30 December 2008); https://doi.org/10.1117/12.820993

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KEYWORDS

Optical coherence tomography

Doppler tomography

Tissues

Coherence imaging

Tissue engineering

Electron microscopy

Microfluidics

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