Laparoscopic optical coherence tomographic imaging of human ovarian cancer

Lida P. Hariri; Garret T. Bonnema; Kathy Schmidt; Vrushali Korde; Amy M. Winkler; Kenneth Hatch; Molly Brewer; Jennifer K. Barton

doi:10.1117/12.809167

23 February 2009 Laparoscopic optical coherence tomographic imaging of human ovarian cancer

Lida P. Hariri, Garret T. Bonnema, Kathy Schmidt, Vrushali Korde, Amy M. Winkler, Kenneth Hatch, Molly Brewer, Jennifer K. Barton

Author Affiliations +

Proceedings Volume 7169, Advanced Biomedical and Clinical Diagnostic Systems VII; 71690S (2009) https://doi.org/10.1117/12.809167
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Ovarian cancer is the fourth leading cause of cancer-related death among women. If diagnosed at early stages, 5-year survival rate is 94%, but drops to 68% for regional disease and 29% for distant metastasis; only 19% of cases are diagnosed at early, localized stages. Optical coherence tomography is a recently emerging non-destructive imaging technology, achieving high axial resolutions (10-20 µm) at imaging depths up to 2 mm. Previously, we studied OCT in normal and diseased human ovary ex vivo. Changes in collagen were suggested with several images that correlated with changes in collagen seen in malignancy. Areas of necrosis and blood vessels were also visualized using OCT, indicative of an underlying tissue abnormality. We recently developed a custom side-firing laparoscopic OCT (LOCT) probe fabricated for in vivo imaging. The LOCT probe, consisting of a 38 mm diameter handpiece terminated in a 280 mm long, 4.6 mm diameter tip for insertion into the laparoscopic trocar, is capable of obtaining up to 9.5 mm image lengths at 10 µm axial resolution. In this pilot study, we utilize the LOCT probe to image one or both ovaries of 17 patients undergoing laparotomy or transabdominal endoscopy and oophorectomy to determine if OCT is capable of differentiating normal and neoplastic ovary. We have laparoscopically imaged the ovaries of seventeen patients with no known complications. Initial data evaluation reveals qualitative distinguishability between the features of undiseased post-menopausal ovary and the cystic, non-homogenous appearance of neoplastic ovary such as serous cystadenoma and endometroid adenocarcinoma.

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Lida P. Hariri, Garret T. Bonnema, Kathy Schmidt, Vrushali Korde, Amy M. Winkler, Kenneth Hatch, Molly Brewer, and Jennifer K. Barton "Laparoscopic optical coherence tomographic imaging of human ovarian cancer", Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71690S (23 February 2009); https://doi.org/10.1117/12.809167

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KEYWORDS

Optical coherence tomography

Ovary

Laparoscopy

Ovarian cancer

Tissues

Glasses

Coherence imaging

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