Aptamer-based localized surface plasmon resonance sensor for monitoring glycated proteins

Rui Zheng; Brent D. Cameron

doi:10.1117/12.875284

11 February 2011 Aptamer-based localized surface plasmon resonance sensor for monitoring glycated proteins

Rui Zheng, Brent D. Cameron

Author Affiliations +

Proceedings Volume 7911, Plasmonics in Biology and Medicine VIII; 79110E (2011) https://doi.org/10.1117/12.875284
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

The peak extinction wavelength of the nano-size noble metal localized surface plasmon resonance (LSPR) spectrum is unexpectedly sensitive to nanoparticle size, shape, and local external dielectric environment. This sensitivity to the environment has enabled the development of a new class of nanoscale affinity biosensors. Aptamer (single strand DNA) based gold nanorods (Au NRs) and magnetic beads (MBs) combined LSPR biosensor has been developed for the rapid and label-free detection of glycated proteins in small solution volumes. An aptamer self-assembly monolayer (SAM) functionalized surface plasmon resonance sensor has also been developed for comparison purposes. For demoonstration purposes, albumin and thrombin are used initially as the target proteins. The ability to monitor such molecules in the body could facilitate the diagnosis and treatment of diabetic patients.

Citation Download Citation

Rui Zheng and Brent D. Cameron "Aptamer-based localized surface plasmon resonance sensor for monitoring glycated proteins", Proc. SPIE 7911, Plasmonics in Biology and Medicine VIII, 79110E (11 February 2011); https://doi.org/10.1117/12.875284

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