Multifunctional hybrid nanoparticles for two-photon fluorescence imaging and photodynamic therapy

Patrice L. Baldeck; Mathieu Maurin; Cecile Philipot; Soraya Zaiba; Thibault Gallavardin; Olivier Maury; Chantal Andraud; Fabien Dubois; Alain Ibanez; Frédéric Lerouge; Stéphane Parola; Olivier Stephan; Baudwin van Der Sanden

doi:10.1117/12.877759

21 February 2011 Multifunctional hybrid nanoparticles for two-photon fluorescence imaging and photodynamic therapy

Patrice L. Baldeck, Mathieu Maurin, Cecile Philipot, Soraya Zaiba, Thibault Gallavardin, Olivier Maury, Chantal Andraud, Fabien Dubois, Alain Ibanez, Frédéric Lerouge, Stéphane Parola, Olivier Stephan, Baudwin van Der Sanden

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Proceedings Volume 7935, Organic Photonic Materials and Devices XIII; 79350S (2011) https://doi.org/10.1117/12.877759
Event: SPIE OPTO, 2011, San Francisco, California, United States

Abstract

We review our work on several strategies to elaborate multifunctional nanoparticules for two-photon imaging or/and photodynamic therapy. Our first strategy is based on the incorporation of two-photon hydrophobic fluorophors in bio-compatible pluronic micelles using the mini-emulsion technique. Our second strategy is based on fluorescent organic nanocrystal grown in silicate spheres. These core-shell hybrid nanoparticles are obtained by a spray-drying process from sol-gel solutions. Our third strategy consists in the encapsulation of hydrophilic molecules in the water core of gold nanospheres. They are obtained by a stabilized emulsion in biphasic liquid-liquid medium without surfactant.

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Patrice L. Baldeck, Mathieu Maurin, Cecile Philipot, Soraya Zaiba, Thibault Gallavardin, Olivier Maury, Chantal Andraud, Fabien Dubois, Alain Ibanez, Frédéric Lerouge, Stéphane Parola, Olivier Stephan, and Baudwin van Der Sanden "Multifunctional hybrid nanoparticles for two-photon fluorescence imaging and photodynamic therapy", Proc. SPIE 7935, Organic Photonic Materials and Devices XIII, 79350S (21 February 2011); https://doi.org/10.1117/12.877759

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KEYWORDS

Nanoparticles

Luminescence

Gold

Molecules

Nanocrystals

Silicates

Sol-gels

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