Optimization of monolithic columns for microfluidic devices

Jayson V. Pagaduan; Weichun Yang; Adam T. Woolley

doi:10.1117/12.884265

13 May 2011 Optimization of monolithic columns for microfluidic devices

Jayson V. Pagaduan, Weichun Yang, Adam T. Woolley

Proceedings Volume 8031, Micro- and Nanotechnology Sensors, Systems, and Applications III; 80311V (2011) https://doi.org/10.1117/12.884265
Event: SPIE Defense, Security, and Sensing, 2011, Orlando, Florida, United States

Abstract

Monolithic columns offer advantages as solid-phase extractors because they offer high surface area that can be tailored to a specific function, fast mass transport, and ease of fabrication. Porous glycidyl methacrylate-ethylene glycol dimethacrylate monoliths were polymerized in-situ in microfluidic devices, without pre-treatment of the poly(methyl methacrylate) channel surface. Cyclohexanol, 1-dodecanol and Tween 20 were used to control the pore size of the monoliths. The epoxy groups on the monolith surface can be utilized to immobilize target-specific probes such as antibodies, aptamers, or DNA for biomarker detection. Microfluidic devices integrated with solid-phase extractors should be useful for point-of-care diagnostics in detecting specific biomarkers from complex biological fluids.

Citation Download Citation

Jayson V. Pagaduan, Weichun Yang, and Adam T. Woolley "Optimization of monolithic columns for microfluidic devices", Proc. SPIE 8031, Micro- and Nanotechnology Sensors, Systems, and Applications III, 80311V (13 May 2011); https://doi.org/10.1117/12.884265

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