Repair of damage and stimulation of growth cone response following laser induced sub-axotomy

Tao Wu; Samarendra Mohanty; Jill Miotke; Ronald Meyer; Michael Berns

doi:10.1117/12.907454

9 February 2012 Repair of damage and stimulation of growth cone response following laser induced sub-axotomy

Tao Wu, Samarendra Mohanty, Jill Miotke, Ronald Meyer, Michael Berns

Author Affiliations +

Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 820761 (2012) https://doi.org/10.1117/12.907454
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

In this paper we induced sub-axotomy axonal damage and repair by use of the laser microbeam in cultured retinal ganglion cells. When growth cones are near the damaged site of an axon, some cases will respond to the damage by extending filopodia towards the damaged axon. In some cases, the filopodia touch the damaged site. These experiments suggest that guidance cues that are sensed by the growth cones are released from the damaged site. These results also indicate that axon growth cone have a role in repair of the neuronal damage.

Citation Download Citation

Tao Wu, Samarendra Mohanty, Jill Miotke, Ronald Meyer, and Michael Berns "Repair of damage and stimulation of growth cone response following laser induced sub-axotomy", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 820761 (9 February 2012); https://doi.org/10.1117/12.907454

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