Modeling the effect of refraction on OCT imaging of lung tissue: a ray-tracing approach

Fatemeh N. Golabchi; Ali Golabchi; Dana H. Brooks; Andrew Gouldstone; Charles A. DiMarzio

doi:10.1117/12.909649

10 February 2012 Modeling the effect of refraction on OCT imaging of lung tissue: a ray-tracing approach

Fatemeh N. Golabchi, Ali Golabchi, Dana H. Brooks, Andrew Gouldstone, Charles A. DiMarzio

Proceedings Volume 8227, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX; 82271R (2012) https://doi.org/10.1117/12.909649
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Determining the structure of lung tissue is difficult in ex-vivo samples. Optical coherence tomography (OCT) can image alveoli but ignores optical effects that distort the images. For example, light refracts and changes speed at the alveolar air-tissue surface. We employ ray-tracing to model OCT imaging with directional and speed changes included, using spherical shapes in 2D. Results show apparent thickening of inter-aveolar walls and distortion of shape and depth. Our approach suggests a correction algorithm by combining the model with image analysis. Distortion correction will allow inference of tissue mechanical properties and deeper imaging.

Citation Download Citation

Fatemeh N. Golabchi, Ali Golabchi, Dana H. Brooks, Andrew Gouldstone, and Charles A. DiMarzio "Modeling the effect of refraction on OCT imaging of lung tissue: a ray-tracing approach", Proc. SPIE 8227, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX, 82271R (10 February 2012); https://doi.org/10.1117/12.909649

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