Raman spectroscopy of blood in-vitro

A. E. Villanueva-Luna; J. Castro-Ramos; S. Vazquez-Montiel; A. Flores-Gil; C. M. Ortiz-Lima; J. A. Delgado-Atencio

doi:10.1117/12.908689

2 February 2012 Raman spectroscopy of blood in-vitro

A. E. Villanueva-Luna, J. Castro-Ramos, S. Vazquez-Montiel, A. Flores-Gil, C. M. Ortiz-Lima, J. A. Delgado-Atencio

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Proceedings Volume 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV; 82291D (2012) https://doi.org/10.1117/12.908689
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

We present Raman spectra from a sample of 8 volunteers that have different type of blood. The experimental data were carried out using a 785 nm excitation laser and an ocean optics spectrometer of 6 cm^-1 resolution, with a used spectral region from 1000 to 1800 cm^-1. We find Raman features at 1000 and 1542 cm^-1 regarded with hemoglobin and its derivatives. Also we find Raman features at 1248 and 1342 cm^-1 that are now regarded with pure fibrin. In this work, we use Principal Component analysis (PCA) to determine all variations of our samples, which allows us to define a classification of the influence of the blood type. Finally, we found vibrational lines of cholesterol, glucose and triglycerides that are reported in literature.

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A. E. Villanueva-Luna, J. Castro-Ramos, S. Vazquez-Montiel, A. Flores-Gil, C. M. Ortiz-Lima, and J. A. Delgado-Atencio "Raman spectroscopy of blood in-vitro", Proc. SPIE 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 82291D (2 February 2012); https://doi.org/10.1117/12.908689

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