Plant virus-resembling optical nano-materials conjugated with anti-EGFR for targeted cancer imaging

Sharad Gupta; Hailey Wilder; A. L. N. Rao; V. I. Vullev; Bahman Anvari

doi:10.1117/12.907730

24 February 2012 Plant virus-resembling optical nano-materials conjugated with anti-EGFR for targeted cancer imaging

Sharad Gupta, Hailey Wilder, A. L. N. Rao, V. I. Vullev, Bahman Anvari

Proceedings Volume 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV; 82330S (2012) https://doi.org/10.1117/12.907730
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

We recently reported the construction of a new type of optically active nano-particles composed of genome-depleted plant infecting brome mosaic virus (BMV) doped with indocyanine green (ICG), an FDA-approved chromophore . We refer to these constructs as optical viral ghosts (OVGs) since only the capsid protein (CP) subunits of BMV remain to encapsulate ICG. Herein, we covalently conjugated the surface of OVGs with anti-epidermal growth factor receptors (anti-EGFR) to target cancerous human bronchial epithelial cells (C-HBECs) in-vitro. Our preliminary results demonstrate the utility of conjugated OVGs for targeted imaging of cancer cells.

Citation Download Citation

Sharad Gupta, Hailey Wilder, A. L. N. Rao, V. I. Vullev, and Bahman Anvari "Plant virus-resembling optical nano-materials conjugated with anti-EGFR for targeted cancer imaging", Proc. SPIE 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV, 82330S (24 February 2012); https://doi.org/10.1117/12.907730

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