Design of nanostructured-based glucose biosensors

Archana Komirisetty; Frances Williams; Aswini Pradhan; Rajini Babu Konda; Hareesh Dondapati; Diptirani Samantaray

doi:10.1117/12.916943

30 March 2012 Design of nanostructured-based glucose biosensors

Archana Komirisetty, Frances Williams, Aswini Pradhan, Rajini Babu Konda, Hareesh Dondapati, Diptirani Samantaray

Author Affiliations +

Proceedings Volume 8344, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2012; 83440C (2012) https://doi.org/10.1117/12.916943
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2012, San Diego, California, United States

Abstract

This paper presents the design of glucose sensors that will be integrated with advanced nano-materials, bio-coatings and electronics to create novel devices that are highly sensitive, inexpensive, accurate, and reliable. In the work presented, a glucose biosensor and its fabrication process flow have been designed. The device is based on electrochemical sensing using a working electrode with bio-functionalized zinc oxide (ZnO) nano-rods. Among all metal oxide nanostructures, ZnO nano-materials play a significant role as a sensing element in biosensors due to their properties such as high isoelectric point (IEP), fast electron transfer, non-toxicity, biocompatibility, and chemical stability which are very crucial parameters to achieve high sensitivity. Amperometric enzyme electrodes based on glucose oxidase (GOx) are used due to their stability and high selectivity to glucose. The device also consists of silicon dioxide and titanium layers as well as platinum working and counter electrodes and a silver/silver chloride reference electrode. Currently, the biosensors are being fabricated using the process flow developed. Once completed, the sensors will be bio-functionalized and tested to characterize their performance, including their sensitivity and stability.

Citation Download Citation

Archana Komirisetty, Frances Williams, Aswini Pradhan, Rajini Babu Konda, Hareesh Dondapati, and Diptirani Samantaray "Design of nanostructured-based glucose biosensors", Proc. SPIE 8344, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2012, 83440C (30 March 2012); https://doi.org/10.1117/12.916943

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KEYWORDS

Biosensors

Glucose

Electrodes

Zinc oxide

Sensors

Silver

Platinum

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