Analysis of conventional swept-source OCT of subglottic stenosis in a
rabbit model

Ashley Hamamoto; Erica Su; Ya-Sin Peaks; Zhongping Chen; Brian J. F. Wong

doi:10.1117/12.2014252

8 March 2013 Analysis of conventional swept-source OCT of subglottic stenosis in a rabbit model

Ashley Hamamoto, Erica Su, Ya-Sin Peaks, Zhongping Chen, Brian J. F. Wong

Author Affiliations +

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 856521 (2013) https://doi.org/10.1117/12.2014252
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Acquired subglottic stenosis is a narrowing of the airway caused by prolonged endotracheal intubation. Currently, there are no non-invasive means to diagnose the disease. A previous study by this same group introduced optical coherence tomography (OCT) as a means of monitoring the progression of stenosis. The aim of the current study was to qualitatively and quantitatively analyze OCT images obtained from a subglottic stenosis model of the rabbit airway. 15 rabbits were used throughout the study, and a MEMs based OCT probe was utilized. The OCT images obtained were analyzed using a free software program, 3D Slicer. The region of scarred tissue was grown out and measured quantitatively. This study demonstrated the feasibility of using a program to quantify the progression of scarring in OCT images, in addition to qualitatively correlating between histology, endoscopic, and OCT images. Future works may include utilization of a long-range probe and use of a pressure necrosis model to better emulate the actual onset of neonatal subglottic stenosis.

Citation Download Citation

Ashley Hamamoto, Erica Su, Ya-Sin Peaks, Zhongping Chen, and Brian J. F. Wong "Analysis of conventional swept-source OCT of subglottic stenosis in a rabbit model", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 856521 (8 March 2013); https://doi.org/10.1117/12.2014252

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