Deconvolution improves the accuracy and depth sensitivity of time-resolved measurements

Mamadou Diop; Keith St. Lawrence

doi:10.1117/12.2004850

25 March 2013 Deconvolution improves the accuracy and depth sensitivity of time-resolved measurements

Mamadou Diop, Keith St. Lawrence

Author Affiliations +

Proceedings Volume 8578, Optical Tomography and Spectroscopy of Tissue X; 85782E (2013) https://doi.org/10.1117/12.2004850
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Time-resolved (TR) techniques have the potential to distinguish early- from late-arriving photons. Since light travelling through superficial tissue is detected earlier than photons that penetrate the deeper layers, time-windowing can in principle be used to improve the depth sensitivity of TR measurements. However, TR measurements also contain instrument contributions – referred to as the instrument-response-function (IRF) – which cause temporal broadening of the measured temporal-point-spread-function (TPSF). In this report, we investigate the influence of the IRF on pathlength-resolved absorption changes (Δμ_a) retrieved from TR measurements using the microscopic Beer-Lambert law (MBLL). TPSFs were acquired on homogeneous and two-layer tissue-mimicking phantoms with varying optical properties. The measured IRF and TPSFs were deconvolved to recover the distribution of time-of-flights (DTOFs) of the detected photons. The microscopic Beer-Lambert law was applied to early and late time-windows of the TPSFs and DTOFs to access the effects of the IRF on pathlength-resolved Δμ_a. The analysis showed that the late part of the TPSFs contains substantial contributions from early-arriving photons, due to the smearing effects of the IRF, which reduced its sensitivity to absorption changes occurring in deep layers. We also demonstrated that the effects of the IRF can be efficiently eliminated by applying a robust deconvolution technique, thereby improving the accuracy and sensitivity of TR measurements to deep-tissue absorption changes.

Citation Download Citation

Mamadou Diop and Keith St. Lawrence "Deconvolution improves the accuracy and depth sensitivity of time-resolved measurements", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85782E (25 March 2013); https://doi.org/10.1117/12.2004850

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
5 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Absorption

Photons

Tissue optics

Optical properties

Deconvolution

Tissues

Scattering

Show All Keywords

Keywords/Phrases

Search In:

Publication Years