Sparse-sampling parallel Raman/SERS microspectroscopy for high-throughput molecular analysis of micro and nanoparticles

Ji Qi; Wei-Chuan Shih

doi:10.1117/12.2005718

22 February 2013 Sparse-sampling parallel Raman/SERS microspectroscopy by active illumination for high-throughput molecular analysis of micro and nanoparticles

Ji Qi, Wei-Chuan Shih

Author Affiliations +

Proceedings Volume 8587, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI; 85871N (2013) https://doi.org/10.1117/12.2005718
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We present the applications of parallel Raman/SERS microspectroscopy by active illumination for simultaneously obtaining the full Raman/SERS spectra from multiple points within a field of view ~100 x 100 μm2 and ~micron spatial resolution. Two schemes have been employed in these studies: line-scan and programmable active illumination. We demonstrate the rapid classification of microparticles with similar shape, size and refractive index based on their chemical composition. We also demonstrate the rapid microanalysis of self-assembled monolayers on various types of gold nanostructures via SERS.

Citation Download Citation

Ji Qi and Wei-Chuan Shih "Sparse-sampling parallel Raman/SERS microspectroscopy by active illumination for high-throughput molecular analysis of micro and nanoparticles", Proc. SPIE 8587, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI, 85871N (22 February 2013); https://doi.org/10.1117/12.2005718

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