Comparison of cone and cone shell configuration for depth sensitive fluorescence measurements in turbid media

Yi Hong Ong; Quan Liu

doi:10.1117/12.2038834

4 March 2014 Comparison of cone and cone shell configuration for depth sensitive fluorescence measurements in turbid media

Yi Hong Ong, Quan Liu

Author Affiliations +

Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 89260J (2014) https://doi.org/10.1117/12.2038834
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

We have developed a novel cone shell illumination and detection configurations using combination of axicon lenses for depth sensitive fluorescence spectroscopy. The probe was demonstrated experimentally to be able to selectively detecting fluorescence from different depths from a two-layered turbid agar phantom. In addition to enhanced contrast of subsurface fluorescence measurement as compared to a conventional cone configuration implemented by a microscope objective lens, the axicon lenses based setup eliminated the need of moving the objective lens up or down to achieve depth sensitive measurements, which effectively improves the consistency of optical coupling thus would be preferred in a clinical setting.

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Yi Hong Ong and Quan Liu "Comparison of cone and cone shell configuration for depth sensitive fluorescence measurements in turbid media", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89260J (4 March 2014); https://doi.org/10.1117/12.2038834

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KEYWORDS

Luminescence

Axicons

Objectives

Lenses

Fluorescence spectroscopy

Microscopes

Tissue optics

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