Nonadiabatic tapered optical fiber biosensor for detection of potassium ion using DNA aptamer in neural application

M. I. Zibaii; H. Latifi; A. Asadollahi

doi:10.1117/12.2059036

2 June 2014 Nonadiabatic tapered optical fiber biosensor for detection of potassium ion using DNA aptamer in neural application

M. I. Zibaii, H. Latifi, A. Asadollahi

Author Affiliations +

Proceedings Volume 9157, 23rd International Conference on Optical Fibre Sensors; 91574K (2014) https://doi.org/10.1117/12.2059036
Event: OFS2014 23rd International Conference on Optical Fiber Sensors, 2014, Santander, Spain

Abstract

A single-mode nonadiabatic tapered optical fiber (NATOF) biosensor based on ssDNA aptamer for detection of potassium ion (K⁺) was developed. Upon binding to K+, the G-rich single-stranded DNA can fold into the G-quadruplex structure, thus allowing the formation of G-quadruplex complex after incubation with K⁺ which is led to changing in refractive index (RI). Under optimum conditions, the wavelength shift was proportional to the concentration of K⁺ in the range of 10 ×10^-4 to 2×10^-2 mM. A detection limit of 4.5×10^-4 was achieved. Moreover, this method was able to detect K⁺ with high selectivity in the presence of Na⁺ ion of biological fluids.

Citation Download Citation

M. I. Zibaii, H. Latifi, and A. Asadollahi "Nonadiabatic tapered optical fiber biosensor for detection of potassium ion using DNA aptamer in neural application", Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 91574K (2 June 2014); https://doi.org/10.1117/12.2059036

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