Noninvasive detection of glucose level based on tunable pulsed laser induced photoacoustic technique

Zhong Ren; Guodong Liu; Zhen Huang

doi:10.1117/12.2069636

3 December 2014 Noninvasive detection of glucose level based on tunable pulsed laser induced photoacoustic technique

Zhong Ren, Guodong Liu, Zhen Huang

Proceedings Volume 9297, International Symposium on Optoelectronic Technology and Application 2014: Laser and Optical Measurement Technology; and Fiber Optic Sensors; 929709 (2014) https://doi.org/10.1117/12.2069636
Event: International Symposium on Optoelectronic Technology and Application 2014, 2014, Beijing, China

Abstract

This paper presents the preliminary investigation of glucose measurement based on tunable pulsed laser induced photoacoustic technique. A photoacoustic glucose detection set-up with forward mode was established. Meanwhile, a 532nm pumped Nd:YAG optical parametric oscillator(OPO) pulsed laser was employed as the photoacoustic signal excitation light source and a confocal PZT transducer was used as photoacoustic signal detector. In experiments, glucose aqueous solutions with several different concentrations were loaded in quartz cuvette in turn and irradiated by focused laser beam, the time-resolved photoacoustic signals were gotten with average of 512 times, the photoacoustic peak-to-peak(PP) value of all concentrations were gotten from 1300nm to 2300nm with interval of 10nm, the characteristic wavelengths of glucose were found via the difference and one order derivative spectral technique. Two optimum characteristic wavelengths were preliminarily chosen via the least square fitting algorithm, their predicted concentration errors were all less than 0.62mmol/dl.

Citation Download Citation

Zhong Ren, Guodong Liu, and Zhen Huang "Noninvasive detection of glucose level based on tunable pulsed laser induced photoacoustic technique", Proc. SPIE 9297, International Symposium on Optoelectronic Technology and Application 2014: Laser and Optical Measurement Technology; and Fiber Optic Sensors, 929709 (3 December 2014); https://doi.org/10.1117/12.2069636

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