Resonant Raman spectra of grades of human brain glioma tumors reveal the content of tryptophan by the 1588 cm-1 mode

Yan Zhou; Cheng-hui Liu; Lixin Zhou; Ke Zhu; Yulong Liu; Lin Zhang; Susie Boydston-White; Gangge Cheng; Yang Pu; Das Bidyut; Robert R. Alfano

doi:10.1117/12.2079458

11 March 2015 Resonant Raman spectra of grades of human brain glioma tumors reveal the content of tryptophan by the 1588 cm^-1 mode

Yan Zhou, Cheng-hui Liu, Lixin Zhou, Ke Zhu, Yulong Liu, Lin Zhang, Susie Boydston-White, Gangge Cheng, Yang Pu, Das Bidyut, Robert R. Alfano

Author Affiliations +

Proceedings Volume 9318, Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 931810 (2015) https://doi.org/10.1117/12.2079458
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

RR spectra of brain normal tissue, gliomas in low grade I and II, and malignant glioma tumors in grade III and IV were measured using a confocal micro Raman spectrometer. This report focus on the relative contents of tryptophan (W) in various grades of brain glioma tumors by the intrinsic molecular resonance Raman (RR) spectroscopy method using the 1588cm^-1 of tryptophan mode by 532 nm excitation. The RR spectra of key fingerprints of tryptophan, with a main vibrational mode at 1588cm^-1 (W8b), were observed. It was found that tryptophan contribution was accumulated in grade I to IV gliomas and the mode of 1588cm^-1 in grade III and IV malignant gliomas were enhanced by resonance.

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Yan Zhou, Cheng-hui Liu, Lixin Zhou, Ke Zhu, Yulong Liu, Lin Zhang, Susie Boydston-White, Gangge Cheng, Yang Pu, Das Bidyut, and Robert R. Alfano "Resonant Raman spectra of grades of human brain glioma tumors reveal the content of tryptophan by the 1588 cm^-1 mode", Proc. SPIE 9318, Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 931810 (11 March 2015); https://doi.org/10.1117/12.2079458

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