Dynamic diffuse optical tomography for assessing changes of breast tumors during neoadjuvant chemotherapy

Jacqueline E. Gunther; Emerson Lim; Hyun Keol Kim; Mindy Brown; Susan Refice; Kevin Kalinsky; Dawn Hershman; Andreas H. Hielscher

doi:10.1117/12.2079435

12 March 2015 Dynamic diffuse optical tomography for assessing changes of breast tumors during neoadjuvant chemotherapy

Jacqueline E. Gunther, Emerson Lim, Hyun Keol Kim, Mindy Brown, Susan Refice, Kevin Kalinsky, Dawn Hershman, Andreas H. Hielscher

Author Affiliations +

Proceedings Volume 9319, Optical Tomography and Spectroscopy of Tissue XI; 93190C (2015) https://doi.org/10.1117/12.2079435
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We have developed a dynamic diffuse optical tomography imaging system that is capable of 3D imaging of both breasts simultaneously. In an ongoing study subjects receiving neoadjuvant chemotherapy are imaged at 6 time points throughout their 5-month treatment. At each time point the subjects preform a breath hold to observe the hemodynamic effects in the breasts. For each session the percent change of various hemodynamic parameters during the breath hold is determined. Preliminary results from show statistically significant differences in washout rates and deoxyhemoglobin changes at the 2-week imaging point between subjects that respond and do not respond to treatment.

Citation Download Citation

Jacqueline E. Gunther, Emerson Lim, Hyun Keol Kim, Mindy Brown, Susan Refice, Kevin Kalinsky, Dawn Hershman, and Andreas H. Hielscher "Dynamic diffuse optical tomography for assessing changes of breast tumors during neoadjuvant chemotherapy", Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93190C (12 March 2015); https://doi.org/10.1117/12.2079435

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