Mixture of learners for cancer stem cell detection using CD13 and H and E stained images

Oğuzhan Oğuz; Cem Emre Akbaş; Maen Mallah; Kasım Taşdemir; Ece Akhan Güzelcan; Christian Muenzenmayer; Thomas Wittenberg; Ayşegül Üner; A. Enis Cetin; Rengül Çetin Atalay

doi:10.1117/12.2216113

23 March 2016 Mixture of learners for cancer stem cell detection using CD13 and H and E stained images

Oğuzhan Oğuz, Cem Emre Akbaş, Maen Mallah, Kasım Taşdemir, Ece Akhan Güzelcan, Christian Muenzenmayer, Thomas Wittenberg, Ayşegül Üner, A. Enis Cetin, Rengül Çetin Atalay

Author Affiliations +

Proceedings Volume 9791, Medical Imaging 2016: Digital Pathology; 97910Y (2016) https://doi.org/10.1117/12.2216113
Event: SPIE Medical Imaging, 2016, San Diego, California, United States

Abstract

In this article, algorithms for cancer stem cell (CSC) detection in liver cancer tissue images are developed. Conventionally, a pathologist examines of cancer cell morphologies under microscope. Computer aided diagnosis systems (CAD) aims to help pathologists in this tedious and repetitive work. The first algorithm locates CSCs in CD13 stained liver tissue images. The method has also an online learning algorithm to improve the accuracy of detection. The second family of algorithms classify the cancer tissues stained with H and E which is clinically routine and cost effective than immunohistochemistry (IHC) procedure. The algorithms utilize 1D-SIFT and Eigen-analysis based feature sets as descriptors. Normal and cancerous tissues can be classified with 92.1% accuracy in H and E stained images. Classification accuracy of low and high-grade cancerous tissue images is 70.4%. Therefore, this study paves the way for diagnosing the cancerous tissue and grading the level of it using H and E stained microscopic tissue images.

Citation Download Citation

Oğuzhan Oğuz, Cem Emre Akbaş, Maen Mallah, Kasım Taşdemir, Ece Akhan Güzelcan, Christian Muenzenmayer, Thomas Wittenberg, Ayşegül Üner, A. Enis Cetin, and Rengül Çetin Atalay "Mixture of learners for cancer stem cell detection using CD13 and H and E stained images", Proc. SPIE 9791, Medical Imaging 2016: Digital Pathology, 97910Y (23 March 2016); https://doi.org/10.1117/12.2216113

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