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7 March 2022 Photobiomodulative effects of laser wavelength on tumor tissue
Hyejin Kim, Yeongeun Kim, Hyun Wook Kang
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Proceedings Volume PC11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology; PC119580G (2022) https://doi.org/10.1117/12.2612146
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Photobiomodulation (PBM) has been investigated for stimulation biological processes including wound healing and pain recovery. Therefore, in this study, the effects of PBM under BL, Visible, and NIR laser irradiations on prostate cancer cells were evaluated to establish safety margins. In in vitro and in vivo studies, BL showed upregulated expression of VEGF, HIF-1α, and EGFR, whereas TGF- β1 was downregulated. These results suggested that BL irradiation can stimulate cancer cell proliferation, angiogenesis, and hypoxia, leading to aggressive tumor growth. These outcomes can provide a safety margin for the response of PBM-related stimulation after laser treatment.
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Hyejin Kim, Yeongeun Kim, and Hyun Wook Kang "Photobiomodulative effects of laser wavelength on tumor tissue", Proc. SPIE PC11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology, PC119580G (7 March 2022); https://doi.org/10.1117/12.2612146
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KEYWORDS
Tumors
Cancer
Laser tissue interaction
Oncology
Hypoxia
Ultraviolet radiation
Laser therapeutics
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