Performance characterisation of a holographic Fourier domain diffuse correlation spectroscopy instrument

Edward James; Samuel Powell; Peter Munro

doi:10.1117/12.2605455

2 March 2022 Performance characterisation of a holographic Fourier domain diffuse correlation spectroscopy instrument

Edward James, Samuel Powell, Peter Munro

Proceedings Volume PC11959, Dynamics and Fluctuations in Biomedical Photonics XIX; PC1195909 (2022) https://doi.org/10.1117/12.2605455
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We have previously demonstrated a novel Fourier domain diffuse correlation spectroscopy instrument that makes use of holographic camera-based detection, and which is capable of making in vivo pulsatile flow measurements. In this work, we detail considerations to further characterise the signal-to-noise ratio performance of our system. These include demonstration and elimination of laser multimode behaviour, and correction for the camera's modulation transfer function to ensure faithful reconstruction of measured intensity profiles. We document the effect of varying laser source power, and also demonstrate a technique to remove spatiotemporally correlated noise sources to reveal the performance limit of our instrument.

Conference Presentation

Citation Download Citation

Edward James, Samuel Powell, and Peter Munro "Performance characterisation of a holographic Fourier domain diffuse correlation spectroscopy instrument", Proc. SPIE PC11959, Dynamics and Fluctuations in Biomedical Photonics XIX, PC1195909 (2 March 2022); https://doi.org/10.1117/12.2605455

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