Detection of early-stage glaucoma with a depth-resolved optical attenuation coefficient

Shuang Chang; Theodore Leng; Sylvia L. Groth; Audrey K. Bowden

doi:10.1117/12.2609866

3 March 2022 Detection of early-stage glaucoma with a depth-resolved optical attenuation coefficient

Shuang Chang, Theodore Leng, Sylvia L. Groth, Audrey K. Bowden

Author Affiliations +

Proceedings Volume PC11974, Biomedical Applications of Light Scattering XII; PC1197407 (2022) https://doi.org/10.1117/12.2609866
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Detecting early-stage glaucoma remains a challenge in current clinical practice. In this study we assessed the ability of the optical attenuation coefficient (AC) of the retinal nerve fiber layer (RNFL) to detect early-stage glaucoma, evaluated the effectiveness of the AC against the conventional RNFL thickness measurement, and introduced new depth-dependent diagnostic parameters. Our results showed statistically significant differences between ACs extracted from the RNFL of healthy eyes and early-stage glaucoma eyes, including glaucoma suspects and mild open-angle glaucoma. We also showed that depth-dependent AC analysis is an even more sensitive measure to monitor and detect early signs of glaucoma.

Conference Presentation

Citation Download Citation

Shuang Chang, Theodore Leng, Sylvia L. Groth, and Audrey K. Bowden "Detection of early-stage glaucoma with a depth-resolved optical attenuation coefficient", Proc. SPIE PC11974, Biomedical Applications of Light Scattering XII, PC1197407 (3 March 2022); https://doi.org/10.1117/12.2609866

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