Theoretical and practical considerations in translational optoretinography

Ravi S. Jonnal; Reddikumar Maddipatla; Kari V. Vienola; Denise Valente; Robert J. Zawadzki

doi:10.1117/12.2652250

9 March 2023 Theoretical and practical considerations in translational optoretinography

Ravi S. Jonnal, Reddikumar Maddipatla, Kari V. Vienola, Denise Valente, Robert J. Zawadzki

Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC1236707 (2023) https://doi.org/10.1117/12.2652250
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Optoretinography (ORG) is an emerging effort to noninvasively measure the functional responses of retinal neurons. We and other groups have previously shown that cellular-resolution coherent imaging of photoreceptors can reveal microscopic stimulus-evoked changes in the shape of photoreceptors. Such methods track the position of cellular features using phase differences among them. Here we present a novel method using low-cost OCT hardware that monitors the phase velocity of these features instead. The primary advantage of this system is elimination of the need to resolve and track single cells using costly and complicated optical and computational methods. This system may permit rapid, high-throughput measurement of retinal function healthy volunteers and patients.

Conference Presentation

Citation Download Citation

Ravi S. Jonnal, Reddikumar Maddipatla, Kari V. Vienola, Denise Valente, and Robert J. Zawadzki "Theoretical and practical considerations in translational optoretinography", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC1236707 (9 March 2023); https://doi.org/10.1117/12.2652250

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KEYWORDS

Optical coherence tomography

Coherence imaging

Macula

Neurons

Optical tracking

Phase velocity

Signal to noise ratio

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