Characterizing intestinal fibrosis using endoscopic strain and spectroscopic photoacoustic imaging (Conference Presentation)

Linyu Ni; Xiaorui Peng; Yunhao Zhu; Laura Johnson; Kathryn A. Eaton; Jonathan Rubin; Peter Higgins; Xueding Wang; Guan Xu

doi:10.1117/12.2650293

15 March 2023 Characterizing intestinal fibrosis using endoscopic strain and spectroscopic photoacoustic imaging (Conference Presentation)

Linyu Ni, Xiaorui Peng, Yunhao Zhu, Laura Johnson, Kathryn A. Eaton, Jonathan Rubin, Peter Higgins, Xueding Wang, Guan Xu

Author Affiliations +

Proceedings Volume PC12381, Optical Elastography and Tissue Biomechanics X; PC123810N (2023) https://doi.org/10.1117/12.2650293
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Quantification of fibrosis is critical for the management of inflammatory bowel disease. In this study, photoacoustic (PA) strain imaging were used to estimate intestinal stiffness during the progression of intestinal fibrosis in 23 rabbits in vivo. The tissue was then harvested to measure the young’s modulus ex vivo. Collagen-to-Hb ratio measured using spectroscopic PA imaging was also recorded. Results show that PA-strain is positively correlated to Young’s Modulus with a correlation coefficient of 0.81. PA-strain distinguishes the low histological fibrosis (0-2) and high histological fibrosis (3-5) significantly (p-value<0.001). Collagen-to-Hb ratio and PA-strain are highly correlated with the histological fibrosis (0-5) with correlation of 0.67 and 0.64, respectively.

Conference Presentation

Citation Download Citation

Linyu Ni, Xiaorui Peng, Yunhao Zhu, Laura Johnson, Kathryn A. Eaton, Jonathan Rubin, Peter Higgins, Xueding Wang, and Guan Xu "Characterizing intestinal fibrosis using endoscopic strain and spectroscopic photoacoustic imaging (Conference Presentation)", Proc. SPIE PC12381, Optical Elastography and Tissue Biomechanics X, PC123810N (15 March 2023); https://doi.org/10.1117/12.2650293

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