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16 March 2023 Acoustic-driven quantitative phase microscope for quantifying cell mechanical properties at sub-cellular level (Conference Presentation)
Yuechuan Lin, Xiang Zhang, Rebecca Elizabeth Zubajlo, Zahid Yaqoob, Brian W. Anthony, Peter T. C. So
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Proceedings Volume PC12389, Quantitative Phase Imaging IX; PC123890H (2023) https://doi.org/10.1117/12.2648478
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
We present an acoustic-driven quantitative phase microscope for quantifying cell biomechanics at sub-cellular level. Longitudinal acoustic standing wave is established as mechanical loadings to deform cells. A reflection quantitative phase microscopy with high axial and lateral resolution is used to quantify the cell deformations. We evaluate cancerous and normal cells undergoing standing wave modulation, where both the time-lapse cell membrane fluctuations and whole-cell volumetric shape changes are measured. Our technique can achieve high throughput, label-free and non-invasive quantification of cell mechanics with high mechanical sensitivity over broad mechanical frequency response range and can potentially be extended to study 3D tissue mechanics with sub-cellular resolution.
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Yuechuan Lin, Xiang Zhang, Rebecca Elizabeth Zubajlo, Zahid Yaqoob, Brian W. Anthony, and Peter T. C. So "Acoustic-driven quantitative phase microscope for quantifying cell mechanical properties at sub-cellular level (Conference Presentation)", Proc. SPIE PC12389, Quantitative Phase Imaging IX, PC123890H (16 March 2023); https://doi.org/10.1117/12.2648478
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KEYWORDS
Microscopes
Acoustics
Cell mechanics
Microscopy
Phase shift keying
Spatial coherence
Spatial resolution
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