Gold nanourchin-based SERS microfluidic platform for immuno-detection of disease biomarkers

Andra-Sorina Tatar; Ioana-Andreea Brezestean; Daniel Marconi; Alia Colnita; Sanda Boca

doi:10.1117/12.2672322

5 October 2023 Gold nanourchin-based SERS microfluidic platform for immuno-detection of disease biomarkers

Andra-Sorina Tatar, Ioana-Andreea Brezestean, Daniel Marconi, Alia Colnita, Sanda Boca

Proceedings Volume PC12648, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XXI; PC126481H (2023) https://doi.org/10.1117/12.2672322
Event: SPIE Nanoscience + Engineering, 2023, San Diego, California, United States

Conference Poster

Abstract

Gold nanourchins (GNUs) have a multitude of tips-and-dips which make them excellent SERS substrates. Herein, GNUs were obtained via a two-step synthesis integrated in a controllable microfluidic setup. GNUs were bio-functionalized with a reporter molecule and a polymeric coating. The detection system relies on antibodies that recognise the cancer biomarker CEA-CAM5. Antibody-antigen binding leads to a proportional aggregation of the particles and SERS enhancement. Integration of the detection system in a microfluidic platform offers a multitude of advantages. Acknowledgement: This work was supported by MCID, CNCS-UEFISCDI through proj.nr.PN-III-P1-1.1-TE-2021-0234 within PNCDI-III, and through the Core Programme proj.nr.PN.23.24.01.02 within PNCDI 2022-2027.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Andra-Sorina Tatar, Ioana-Andreea Brezestean, Daniel Marconi, Alia Colnita, and Sanda Boca "Gold nanourchin-based SERS microfluidic platform for immuno-detection of disease biomarkers", Proc. SPIE PC12648, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XXI, PC126481H (5 October 2023); https://doi.org/10.1117/12.2672322

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