The use of bioelectronic devices for acquiring biological information and delivering therapeutic interventions relies on direct contact with soft bio-tissues. To ensure high-quality signal transductions, the interfaces between bioelectronic devices and bio-tissues must combine signal amplification with stable and conformable contact. Semiconductor-based transistors (e.g., organic electrochemical transistors) have been developed as one of the most advanced technologies for high-performance bio-sensing. However, the rigid mechanical properties and the lack of tissue/skin adhesion from transistors largely prevent the formation of such intimate and long-term stable bio-interfaces. In this talk, I will introduce our material and device designs for introducing three highly important biomimetic properties onto transistor-based biosensors—stretchability, tissue-like softness, and bioadhesive properties. Our rationale designs from the material to the device level allow the realization of these properties with state-of-the-art electrical performance. I will also introduce the strategies and advantages of using these new biomimetic properties in bioelectrical and biochemical sensing.
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