Benchtop to handheld: characterization and optimization of a ring illuminator/detector in a handheld endogenous fluorescence imaging probe

Paula Villarreal; Tyler Peterson; Bofan Song; Rongguang Liang; Gracie Vargas

doi:10.1117/12.3009704

13 March 2024 Benchtop to handheld: characterization and optimization of a ring illuminator/detector in a handheld endogenous fluorescence imaging probe

Paula Villarreal, Tyler Peterson, Bofan Song, Rongguang Liang, Gracie Vargas

Author Affiliations +

Proceedings Volume PC12833, Design and Quality for Biomedical Technologies XVII; PC1283304 (2024) https://doi.org/10.1117/12.3009704
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

This study explores the development of a multimodal imaging system for disease assessment. Various experiments were conducted to evaluate performance in terms of power density, illumination uniformity, and fluorescence emission properties, comparing the handheld setup to the benchtop system. Test samples included phantom gels and oral cancer samples. Preliminary results indicate that the compact LED ring illuminator provided sufficient power for detectable emission signals and improved emission distribution due to sample scattering. The presentation also discusses solutions for achieving a more uniform illumination field and provides insights into imaging in oral epithelial neoplasia with the compact widefield system, along with considerations for translating from a benchtop test system to a compact handheld multimodal system.

Conference Presentation

Citation Download Citation

Paula Villarreal, Tyler Peterson, Bofan Song, Rongguang Liang, and Gracie Vargas "Benchtop to handheld: characterization and optimization of a ring illuminator/detector in a handheld endogenous fluorescence imaging probe", Proc. SPIE PC12833, Design and Quality for Biomedical Technologies XVII, PC1283304 (13 March 2024); https://doi.org/10.1117/12.3009704

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