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13 March 2024 Early radiotherapy response assessment using multi-scale photoacoustic imaging in breast cancer models
Thierry L. Lefebvre, Mariam-Eleni Oraiopoulou, Ellie V. Bunce, Monika A. Golinska, Thomas R. Else, Paul W. Sweeney, Lina Hacker, Steven Kupczak, Yi Cheng, Lisa Young, Sarah E. Bohndiek
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Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128420M (2024) https://doi.org/10.1117/12.3002821
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Longitudinal characterisation of the tumour vascular response to radiotherapy is essential for understanding the role of oxygenation and microvascular disruption in response to therapy. Using multi-scale in vivo photoacoustic imaging (PAI), we assessed early response to two hypofractionated radiotherapy schemes in two human breast cancer models. Mesoscopic and multispectral tomographic photoacoustic imaging was performed 24h pre-, post-radiotherapy, and at endpoint. PAI biomarkers were validated ex vivo with multiplex immunofluorescence using a 20-plex panel developed specifically for vascular response assessment at sub-cellular resolution. PAI captured radiotherapy response, revealing the differential effect between radiotherapy schemes and models with different hypoxia phenotypes.
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Thierry L. Lefebvre, Mariam-Eleni Oraiopoulou, Ellie V. Bunce, Monika A. Golinska, Thomas R. Else, Paul W. Sweeney, Lina Hacker, Steven Kupczak, Yi Cheng, Lisa Young, and Sarah E. Bohndiek "Early radiotherapy response assessment using multi-scale photoacoustic imaging in breast cancer models", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128420M (13 March 2024); https://doi.org/10.1117/12.3002821
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KEYWORDS
Radiotherapy
Photoacoustic imaging
Breast cancer
Tumor growth modeling
Multispectral imaging
Oxygenation
Tomography
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