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Ionizing radiation acoustic imaging (iRAI) is a passive and non-invasive imaging technique that allows for real-time mapping of the radiation dose deposition deep in the body during clinical radiation therapy. In this study, working toward truly quantitative iRAI imaging of radiation dose delivery, correction factors were calibrated through simulation studies to address the special variances in both the detection sensitivity of the 2D matrix array and the reconstruction sensitivity resulting from the delay-and-sum image reconstruction algorithm. By incorporating these compensation factors, volumetric iRAI was employed to accurately map radiation dose deliveries in a soft-tissue phantom. The study demonstrates the potential of iRAI in quantifying the deposition of radiation doses during treatment and facilitating online adaptive radiation therapy.
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Yaocai Huang, Dale Litzenberg, Paul Carson, Issam El Naqa, Wei Zhang, Xueding Wang, "Quantitative ionizing radiation acoustic imaging for radiation dose measurement: a phantom study validation," Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128420Y (13 March 2024); https://doi.org/10.1117/12.2691367