Quantitative photoacoustic imaging utilizing a reference absorber as a fluence marker

Anjali Thomas; Max T. Rietberg; Youri H. W. Meevis; Jasper Vonk; Riemer H. J. A. Slart; Kalloor Joseph Francis

doi:10.1117/12.3002603

13 March 2024 Quantitative photoacoustic imaging utilizing a reference absorber as a fluence marker

Anjali Thomas, Max T. Rietberg, Youri H. W. Meevis, Jasper Vonk, Riemer H. J. A. Slart, Kalloor Joseph Francis

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128422L (2024) https://doi.org/10.1117/12.3002603
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Accurate characterization of carotid plaque composition is essential to identify vulnerable plaque that often leads to stroke. Photoacoustic imaging, which combines optical absorption contrast with ultrasonic imaging depth, shows promise for quantitative examination of carotid plaque. However, unknown light fluence in the tissue makes quantitative photoacoustic imaging challenging. We propose utilizing a known chromophore as a light fluence marker. The feasibility of the approach was tested using simulations on digital phantoms and experiments using tissue-mimicking phantoms. The results show agreement with the actual concentrations, supporting our hypothesis. We intend to extend the approach to ex vivo plaque imaging.

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Anjali Thomas, Max T. Rietberg, Youri H. W. Meevis, Jasper Vonk, Riemer H. J. A. Slart, and Kalloor Joseph Francis "Quantitative photoacoustic imaging utilizing a reference absorber as a fluence marker", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128422L (13 March 2024); https://doi.org/10.1117/12.3002603

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