Optimizing procedures for hybrid infrared fluorescence-optoacoustic functional neuroimaging

Sarah Shaykevich; Daniel Razansky; Shy Shoham

doi:10.1117/12.3003204

13 March 2024 Optimizing procedures for hybrid infrared fluorescence-optoacoustic functional neuroimaging

Sarah Shaykevich, Daniel Razansky, Shy Shoham

Author Affiliations +

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC1284230 (2024) https://doi.org/10.1117/12.3003204
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Optoacoustic tomography (OAT) holds promise for enhancing neuroimaging in the mouse brain. It provides the opportunity for multispectral, mesoscopic, high temporal resolution imaging of neural activity using exogenous and endogenous contrasts. OAT data also presents challenges, such as the need to optimize reconstruction and spectral unmixing parameters as well as the need to overcome light attenuation and nonuniformity. We demonstrate methods to optimize OAT acquisition and analysis for functional neuroimaging, including using a hybrid fluorescence-OAT approach.

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Sarah Shaykevich, Daniel Razansky, and Shy Shoham "Optimizing procedures for hybrid infrared fluorescence-optoacoustic functional neuroimaging", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC1284230 (13 March 2024); https://doi.org/10.1117/12.3003204

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