13 March 2024Monitoring distribution of the therapeutic agent dimethyl sulfoxide (DMSO) with hyperspectral excitation-resolved near-infrared fluorescence imaging
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Dimethyl sulfoxide (DMSO) is one of the most commonly used pharmaceutical drugs in life sciences. It has a wide spectrum of pharmacological effects, including anti-inflammatory effects, local analgesia, weak bacteriostasis and most importantly membrane penetration. We recently developed novel hyperspectral excitation-resolved near-infrared fluorescence imaging system (HER-NIRF) based on a continuous-wave wavelength-swept laser. In this study, this technique is applied for measuring the distribution of the therapeutic agent dimethyl sulfoxide (DMSO) by utilizing solvatochromic shift in the spectral profile of albumin-bound Indocyanine green (ICG). Phantom experiments are conducted to evaluate the performance of the HER-NIRF system. The results show that the distribution of DMSO can be visualized in the wide-field reflection geometry.
Farouk Nouizi,Jaedu Cho,Chang-Seok Kim, andGultekin Gulsen
"Monitoring distribution of the therapeutic agent dimethyl sulfoxide (DMSO) with hyperspectral excitation-resolved near-infrared fluorescence imaging", Proc. SPIE PC12846, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII, PC128460J (13 March 2024); https://doi.org/10.1117/12.3005062
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Farouk Nouizi, Jaedu Cho, Chang-Seok Kim, Gultekin Gulsen, "Monitoring distribution of the therapeutic agent dimethyl sulfoxide (DMSO) with hyperspectral excitation-resolved near-infrared fluorescence imaging," Proc. SPIE PC12846, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII, PC128460J (13 March 2024); https://doi.org/10.1117/12.3005062