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Continuous monitoring of pH and pressure is a common procedure followed by physicians to acquire a clinical picture in gastroesophageal reflux diseases but also the presence of the bile in the gastroesophageal apparatus has been demonstrated to provide important information associated to the damaging effects of the biliary salts on the esophageal mucosa. Results and performances of optical fiber sensors for the simultaneous measurement of bile and pH with the optical fibers will be described together with all the necessary steps followed to arrive to clinical applications. The activity related to the integration of the bile and pH sensors in a single catheter and to the development of a single catheter for the simultaneous measurement of all the three important parameters (pH, bile and pressure) will be fully discussed.
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Francesco Baldini, Francesco Chiavaioli, Cosimo Trono, "Continuous monitoring in gastroesophageal reflux diseases with optical fibers: from the lab to the clinic," Proc. SPIE PC12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics, PC128500M (13 March 2024); https://doi.org/10.1117/12.3009719