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13 March 2024 Unraveling the complexity of thrombosis through high-speed optical imaging on a chip
Yuqi Zhou, Masako Nishikawa, Hiroshi Kanno, Chenqi Zhang, Yuma Ibayashi, Huidong Wang, Hongqian Zhang, Nao Nitta, Yogendra Kanthi, Gustavo Rohde, Kyoji Moriya, Yutaka Yatomi, Keisuke Goda
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Proceedings Volume PC12853, High-Speed Biomedical Imaging and Spectroscopy IX; PC128530J (2024) https://doi.org/10.1117/12.3002308
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Thrombosis remains a global health concern, necessitating research into its underlying mechanisms. Utilizing a high-speed bright-field microscope based on optical frequency-division multiplexing and microfluidics, we performed image-based single-cell profiling and temporal monitoring of circulating platelet aggregates that are the precursors to thrombosis. Our analysis encompassed 41 thrombosis patients, 110 COVID-19 patients, and 11 healthy individuals. By investigating the morphological changes of platelet aggregates under the influence of thrombosis, COVID-19, and COVID-19 vaccination, we observed distinct morphological alterations in platelet aggregates across different conditions, which shed light on the interplay between platelet aggregation and thrombotic events.
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Yuqi Zhou, Masako Nishikawa, Hiroshi Kanno, Chenqi Zhang, Yuma Ibayashi, Huidong Wang, Hongqian Zhang, Nao Nitta, Yogendra Kanthi, Gustavo Rohde, Kyoji Moriya, Yutaka Yatomi, and Keisuke Goda "Unraveling the complexity of thrombosis through high-speed optical imaging on a chip", Proc. SPIE PC12853, High-Speed Biomedical Imaging and Spectroscopy IX, PC128530J (13 March 2024); https://doi.org/10.1117/12.3002308
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KEYWORDS
COVID 19
Optical imaging
Image analysis
Microscopes
Machine learning
Medical research
Microfluidics
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