We present a novel perovskite core-multishell nanoparticle (PNCs@polymer) incorporating silica and poly-lactide-co-glycolic acid, that renders excellent water stability for days, thereby establishing their suitability for biomedical applications. Additionally, we created a dual emission ratiometric sensor by incorporating a nitric oxide (NO)-responsive dye within the polymer shell. These nanosensors showed enhanced emission at 586 nm with increasing NO concentration, while the fluorescence from PNCs at 510 nm remains constant. Furthermore, these nanosensors were used to quantify the extracellular NO concentration released from breast cancer cells pretreated with a NO donor, thereby offering dual advantages of both bioimaging and sensing capabilities.
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