Estimation of light penetration depth in human brain tissue using Mueller polarimetric imaging: ex vivo study in formalin-fixed human cerebral white and gray matter

Omar Rodríguez-Núñez; Romane Gros; Stefano Moriconi; Leonard Felger; Ekkehard Hewer; Theoni Maragkou; Richard McKinley; Angelo Pierangelo; Tatiana Novikova; Philippe Schucht

doi:10.1117/12.3014418

19 June 2024 Estimation of light penetration depth in human brain tissue using Mueller polarimetric imaging: ex vivo study in formalin-fixed human cerebral white and gray matter

Omar Rodríguez-Núñez, Romane Gros, Stefano Moriconi, Leonard Felger, Ekkehard Hewer, Theoni Maragkou, Richard McKinley, Angelo Pierangelo, Tatiana Novikova, Philippe Schucht

Author Affiliations +

Proceedings Volume PC13010, Tissue Optics and Photonics III; PC1301009 (2024) https://doi.org/10.1117/12.3014418
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

During neurooncological surgery the intraoperative visual differentiation of healthy and diseased tissue is often challenging. In our prior work we demonstrated that imaging Mueller polarimetry is a promising tool for both ex- and in-vivo brain tissue differentiation and diagnosis. Apart from the superficial 2D-polarimetric maps of brain fiber tracts that can be generated with IMP, the knowledge of the probing tissue volume is crucial for the estimation of residual tumor thickness and the proximity of underlying fiber tracts. Here, we quantified the penetration depth of a probing light beam by evaluating the polarimetric maps of formalin-fixed (FF) human cerebral corpus callosum sections of different thicknesses measured in reflection, and we extended the analysis to FF gray matter brain sections of different thicknesses. Finally, we evaluated the light penetration depth at different wavelengths. Our findings allow us to define different thresholds of light penetration depth for white and gray brain matter.

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Omar Rodríguez-Núñez, Romane Gros, Stefano Moriconi, Leonard Felger, Ekkehard Hewer, Theoni Maragkou, Richard McKinley, Angelo Pierangelo, Tatiana Novikova, and Philippe Schucht "Estimation of light penetration depth in human brain tissue using Mueller polarimetric imaging: ex vivo study in formalin-fixed human cerebral white and gray matter", Proc. SPIE PC13010, Tissue Optics and Photonics III, PC1301009 (19 June 2024); https://doi.org/10.1117/12.3014418

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KEYWORDS

Polarimetry

Brain tissue

Brain

Brain mapping

Reflection

Visualization

White matter

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