We present a high-quality factor plasmonic biosensor with a metal-2D material-metal (M-2D-M) structure for dengue detection. The modified prism-based plasmonic sensor consists of two layers of aluminum (Al) (30 nm and 7 nm) sandwiching a layer of 2D nanomaterial (MoS2). Each layer of the proposed plasmonic device is engineered using the transfer matrix method, considering critical performance parameters such as sensitivity, quality factor, detection accuracy, and Figure of Merit (FOM). The effect of different 2D nanomaterial layers, e.g., antimonene, black phosphorus, graphene, MXene, and molybdenum disulfide (MoS2), on the sensing parameters is studied in the M-2D-M structure. A monolayer of MoS2 is considered at the top of the M-2D-M structure as a bio-recognition element to study biomolecular interactions. The final plasmonic multilayer structure, Al-MoS2-Al-MoS2, is used for dengue detection by capturing the variation in different blood components, such as plasma, platelets, and hemoglobin, in normal and infected states.
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