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7 June 2024 Advancing SERS biosensing via rational design and automation
Pietro Strobbia
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Proceedings Volume PC13059, Smart Biomedical and Physiological Sensor Technology XXI; PC1305904 (2024) https://doi.org/10.1117/12.3014015
Event: SPIE Defense + Commercial Sensing, 2024, National Harbor, Maryland, United States
Abstract
The pandemic has shown that we need sensitive and deployable diagnostic technologies. Surface-enhanced Raman scattering (SERS) sensors can be an ideal solution for developing such advanced Point-of-Need (PON) diagnostic tests but their limitation is the achievable sensitivity, insufficient compared to what is needed for sensing of viral biomarkers. Noncovalent DNA catalysis mechanisms have been recently exploited for catalytic amplification in SERS assays. These advances used catalytic hairpin assembly (CHA) and other DNA self-assembly processes to develop sensing mechanisms with improved sensitivities. We developed and investigated a reagentless SERS sensing mechanism that uses catalytic amplification based on DNA self-assembly. We will discuss the design of this catalytic sensing mechanism and its automation into a design algorithm.
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Pietro Strobbia "Advancing SERS biosensing via rational design and automation", Proc. SPIE PC13059, Smart Biomedical and Physiological Sensor Technology XXI, PC1305904 (7 June 2024); https://doi.org/10.1117/12.3014015
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KEYWORDS
Design and modelling
Automation
Biosensing
Catalysis
Diagnostic tests
Diagnostics
Directed self assembly
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